Researcher
Sophie Debrock
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Woman and Child (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 7 of 7
- Development of highly multiplexed and ultra-sensitive spatial (multi-)omics assays to disclose and understand the biology of cellular heterogeneity in pre- and post-implantation embryogenesis at the single-cell levelFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- The mutational landscape of in vivo and in vitro human embryogenesisFrom1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Understanding chromosome conformation, 3D nuclear DNA architecture and gene expression in human embryogenesis at single-cell resolutionFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Understanding 3D nuclear DNA architecture and gene expression in single cells: a comprehensive survey in the first days of life.From1 May 2018 → 1 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- A single-cell integrative (epi)genomics and transcriptomics atlas of human preimplantation embryogenesis to understand cause and effect of (epi)genome dynamics in the first days of human developmentFrom1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Single-cell DNA and RNA sequencing of human cleavage and blastocyst stage embryos to study genomic instability and its functional impact on early developmentFrom1 Oct 2013 → 8 Dec 2023Funding: FWO fellowships
- Impact of Belgian legislation on reproductive outcome of medical assisted conception in the Leuven University Fertility CenterFrom1 Jan 2009 → 3 Oct 2016Funding: FWO fellowships
Publications
1 - 10 of 69
- Cumulative pregnancy rates of two strategies: Day 3 fresh embryo transfer followed by Day 3 or Day 5/6 vitrification and embryo transfer: a randomized controlled trial(2024)
Authors: Astrid Van Muylder, Karen Peeraer, Jeroen Luyten, Annouschka Laenen, Carl Spiessens, Sophie Debrock
Pages: 62 - 73 - A multi-omics genome-plus-transcriptome single-cell atlas of human preimplantation development(2023)
Authors: Elia Fernandez Gallardo, Thierry Voet, Sophie Debrock, Joris Vermeesch
- The impact of chronic endometritis on infertility: prevalence, reproductive outcomes, and the role of hysteroscopy as a screening tool(2023)
Authors: Brecht Geysenbergh, Celine Bafort, Anne-Sophie Van Rompuy, Sharon Lie Fong, Sophie Debrock, Joris Vriens, Eline Dancet, Thomas D'Hooghe, Karen Peeraer
Pages: 108 - 115 - Preclinical workup using long-read amplicon sequencing provides families with de novo pathogenic variants access to universal preimplantation genetic testing(2023)
Authors: Olga Tsuiko, Sophie Debrock, Karen Peeraer, Arne Vanhie, Ellen Denayer, Eric Legius, Joris Vermeesch, Hilde Brems, Eftychia Dimitriadou
Pages: 511 - 519 - Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts(2022)
Authors: Tine De Coster, Olga Tsuiko, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Joris Vermeesch
- Single-cell genome-wide concurrent haplotyping and copy-number profiling through genotyping-by-sequencing(2022)
Authors: Sophie Debrock, Yves Moreau, Thierry Voet
- Single-cell genome-wide concurrent haplotyping and copy-number profiling through genotyping-by-sequencing(2022)
Authors: Eftychia Dimitriadou, Sophie Debrock, Olga Tsuiko, Karen Peeraer, Yves Moreau, Thierry Voet, Masoud Zamani Esteki, Joris Vermeesch
- The Ultra-Long Study: A Randomized Controlled Trial Evaluating Long-Term GnRH Downregulation Prior to ART in Women With Endometriosis(2022)
Authors: Carla Tomassetti, Sophie Debrock, Karen Peeraer, Christel Meuleman, Thomas D'Hooghe
Pages: 32 - 33 - Haplotyping-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation(2021)
Authors: Olga Tsuiko, Michiel Vanneste, Sophie Debrock, Heleen Masset, Karen Peeraer, Ellen Denayer, Joris Vermeesch, Eftychia Dimitriadou
- The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis(2021)
Authors: Carla Tomassetti, Sophie Debrock, Karen Peeraer, Christel Meuleman, Thomas D'Hooghe
Pages: 2676 - 2686