Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 7 of 7 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 69
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding the roles of the epigenetic machinery in shaping distinct tumor-associated macrophage phenotypes.From10 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
Publications
1 - 10 of 314
- Evolution of the Experimental Models of Cholangiocarcinoma(2020)
Authors: Chiara Varamo
- Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells(2010)
Authors: Mario di Matteo
Pages: 1039 - 1046 - In vivo antitumoral efficacy of PhAc-ALGP-doxorubicin, an enzyme-activated doxorubicin prodrug, in patient-derived soft tissue sarcoma xenograft models(2017)
Authors: Jasmien Cornillie, Agnieszka Wozniak, Peter Pokreisz, Andrea Casazza, Yemarshet Kelemework Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes, Patrick Schöffski
Pages: 1566 - 1575 - microRNAs in ES Cell Differentiation(2012)
Authors: Emanuele Berardi, Lieven Thorrez, Maurilio Sampaolesi
Pages: H931 - H939 - Podoplanin-Expressing Macrophages (PoEMs) Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer(2019)
Authors: Pawel Jacek Bieniasz-Krzywiec, Max Mazzone
- PRO-INVASIVE TUMOUR-STROMA INTERACTIONS: ROLE OF THE SECRETED OXIDOREDUCTASE CLIC3(2019)
Authors: Juan R Hernandez-Fernaud, Elena Ruengeler, Lisa J Neilson, Shehab Ismail, Iain McNeish, Samuel Atkinson, Sergio Lilla, Alice Santi, Stella M Valenzuela, Karen Blyth, et al.
Pages: 136 - 136 - Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling(2019)
Authors: Shehab Ismail Mohamed, Max Mazzone
- Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency(2015)
Authors: Simon Verheijden, Lien Beckers, Andrea Casazza, Oleg Butovsky, Max Mazzone, Myriam Baes
Pages: 1606 - 20 - Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment(2014)
Authors: Andrea Casazza, Giusy Di Conza, Mathias Wenes, Veronica Finisguerra, Sofie Deschoemaeker, Max Mazzone
Pages: 1743 - 1754 - Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform(2012)
Authors: Andrea Casazza, Max Mazzone
Pages: 234 - 50