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Researcher
Pascale Zimmermann
- Disciplines:Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- Laboratory for Extracellular Vesicle Research (Division)
Responsible
From1 Aug 2008 → Today - Faculty of Medicine (Faculty)
Member
From1 Sep 2002 → 31 Dec 2002 - Department of Human Genetics (Department)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 21
- Targeting syntenin-syndecan (CD138) exosome turnover for multiple myeloma therapyFrom12 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- ExoRAS: a novel, exosome-based K/N-RAS-targeting tool to overcome drug resistance in multiple myelomaFrom1 Oct 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Transient Receptor Potential Channels as Sensors of Extracellular Lipid VesiclesFrom17 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Exploring the added value of exosome-mediated dual targeting in the treatment of pancreatic ductal adenocarcinomaFrom15 May 2021 → 14 May 2023Funding: BOF - various
- Developing a common vaccine against dengue, yellow fever and ZikaFrom15 Jan 2021 → 26 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Exploring strategies for efficient vectorized exosome-based therapy in pancreatic cancerFrom23 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- ExoRAS: Manipulating exosomes involved in intercellular communication to apply KRAS-targeting and overcome drug resistance in multiple myeloma.From22 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- PDZ networking in the biology of extracellular vesicles.From1 Oct 2020 → TodayFunding: BOF - projects
- Syndecan-PDZ scaffolds in the molecular and functional heterogeneity of extracellular vesicles: the role of syntenin in ncRNA transferFrom23 Sep 2019 → 3 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 69
- Downregulation of stromal syntenin sustains AML development(2023)
Authors: Guido David, Pascale Zimmermann
- PDZ scaffolds regulate extracellular vesicle production, composition, and uptake(2023)
Authors: Lukas Hyka, Guido David, Pascale Zimmermann
- Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles(2023)
Authors: Pascale Zimmermann
- The Human PDZome 2.0: Characterization of a New Resource to Test for PDZ Interactions by Yeast Two-Hybrid(2023)
Authors: Pascale Zimmermann
- Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/ Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach(2023)
Authors: Pascale Zimmermann
Pages: 4633 - 4658 - Tetraspanins and syndecans: Partners in crime for 'dealing' exosomes?(2021)
Authors: Guido David, Pascale Zimmermann
Pages: 1101 - 1107 - Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread(2021)
Authors: Pascale Zimmermann
- Syntenin-knock out reduces exosome turnover and viral transduction(2021)
Authors: Rudra Shankar Kashyap, Anton Roebroek, Guido David, Pascale Zimmermann
- A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma(2021)
Authors: Pascale Zimmermann
Pages: 1423 - 1434 - Study of PDZ-Peptide and PDZ-Lipid Interactions by Surface Plasmon Resonance/BIAcore(2021)
Authors: Pascale Zimmermann
Pages: 75 - 87