Organisation
Research Group Molecular Neurobiology (VIB-KU Leuven)
Division
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.
Sub-organisation(s)
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- Laboratory of Interneuron Developmental Dynamics (VIB-KU Leuven)
- Laboratory of Sleep and Synaptic Plasticity (VIB-KU Leuven)
- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven)
- Laboratory of Neuronal Communication (VIB-KU Leuven)
- Laboratory of Neuronal Differentiation (VIB-KU Leuven Center for Brain & Disease Research)
- Laboratory of Emotional Circuit Development (VIB-KU Leuven)
- Laboratory of Membrane Trafficking (VIB-KU Leuven)
- Laboratory of Stem Cell and Developmental Neurobiology (VIB-KU Leuven)
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)
- Laboratory of Glia Biology (VIB-KU Leuven)
Current researchers
1 - 7 of 7 results
- Patrik Verstreken (Responsible)
- Natalia Gunko (Member)
- Véronique Hendrickx (Member)
- Esther Klingler (Member)
- Sebastian Munck (Member)
- Nicolas Peredo (Member)
- Angéle Pouwels (Member)
Projects
1 - 10 of 22
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Flanders BioImaging: Leading Imaging Application Integrated Service and Enablement (FBI-LIAISE)From1 Jan 2023 → TodayFunding: FWO International research infrastructure (IRI)
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- FB-III (“FB triple-I”) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.From1 Feb 2021 → TodayFunding: FWO International research infrastructure (IRI)
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Development of new chemical tools to investigate the role of L-type calcium channels in diseases.From6 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 168
- An accelerated procedure for approaching and imaging of optically branded region of interest in tissue(2021)
Authors: Natalia Gunko
Pages: 205 - 221 - Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism(2019)
Authors: Adrian Martin-Segura, Alvaro Casadome-Perales, Pietro Fazzari, Jose Manuel Mas, Laura Artigas, Raquel Valls, Angel R Nebreda, Carlos Dotti
- Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development(2010)
Authors: Carlos Dotti
Pages: 1343 - 1357 - Glutamatergic Synapse Formation is Promoted by alpha 7-Containing Nicotinic Acetylcholine Receptors(2012)
Authors: Adrian F Lozada, Xulong Wang, Natalia Gunko, Kerri A Massey, Jingjing Duan, Zhaoping Liu, Darwin K Berg
Pages: 7651 - 7661 - Induction of Dendritic Spines by beta 2-Containing Nicotinic Receptors(2012)
Authors: Natalia Gunko
Pages: 8391 - 8400 - Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex(2009)
Authors: Carlos Dotti
Pages: 15344 - 9 - The XLMR gene ACSL4 plays a role in dendritic spine architecture(2009)
Authors: Carlos Dotti
Pages: 657 - 69 - High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A(2014)
Authors: Carlos Dotti
Pages: 864 - 875 - APLP2 regulates neuronal stem cell differentiation during cortical development(2013)
Authors: Bassem Hassan, Carlos Dotti, Bart De Strooper, Annette Gärtner
Pages: 1268 - 77 - Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis(2011)
Authors: Paul P Van Veldhoven, Carlos Dotti
Pages: 1308 - 1315