A paradigm shifting treatment for keratoconus.

Keratoconus is a progressive disease of the cornea that is characterized by corneal thinning and outward bulging in the shape of a cone. This leads to visual impairment if left untreated. A range ofsoft to hard contact lenses are commercially available for visual corrections, but they become inadequate or uncomfortable after prolonged wear or in case of disease progression. The second-line treatment consist of corneal crosslinking or transplantation, but these often still require corrective lenses afterwards. We have developed a new treatment modality for keratoconus patients that can permanently correct their vision and is non-invasive and reversible. In a previous IOF POC CREATE project, we confirmed our hypothesis on an in vitro level, while this IOF POC DEVELOP project serves to deliver an in vivo safety and functional proof-of-concept in a mouse and rabbit animal model respectively. Furthermore, a thorough business plan will be further drafted with the emphasis on a regulatory roadmap and a quantitative market analysis.

Keywords:MEDICAL DEVICE SECTOR

Disciplines:Biomaterials, Ophthalmology