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This unit designs and develops antiviral and antitumor agents, primarily nucleoside, nucleotide or oligonucleotide analogues but also other substances which interact with enzymes involved in nucleic acid metabolism (i.e. DNA polymerase, reverse transcriptase, thymidine kinase, thymidylate kinase, nucleoside phosphorylase, dihydropyrimidine dehydrogenase, adenosine deaminase, S-adenosylhomocysteine hydrolase, IMP dehydrogenase, OMP ...

In the research unit ARKI, internal motion mechanisms in human joints are investigated in particular. Examples are the study of patterns of coupled motion in the cervical spine and in the lumbar spine as well as the study of locking and unlocking mechanisms in the joints of the extremities. Hereby, special attention is devoted to the variability of intra-articular rotation and translation components in healthy subjects and in patients. ...