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The Scheele laboratory focuses on morphogenesis, homeostasis, and tumorigenesis of epithelial organs ranging from a cellular level to the organ scale. More specifically, the Scheele lab studies how healthy tissue architecture and environment prevent or promote the different steps of tumorigenesis. To study these highly dynamic processes, the Scheele lab utilizes and develops state-of-the-art imaging approaches, including 3D whole organ ...

Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.