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Our research interest is in the epigenetic causes of human diseases. We tackle scientific problems by leveraging cutting edge genomic tools, in vitro and in vivo experiments and insights derived from patient samples. This enables us to address questions that were hitherto impossible to be answered. we am thus uniquely poised to characterize the nature of epigenetic signals that are changed in disease, how they are perturbed and how they ...

The CME researchers conduct leading-edge research in various areas of the life sciences. The emphasis is on molecular genetics, cell biology and developmental biology. They also develop technologies to support clinical and basic genetic research at home and abroad. The Center for Human Genetics currently has twenty independent research groups, one of which is the Epigenetic Epidemiology research unit.

Cancers are highly heterogeneous entities, both within a single tumor and across patients. Intratumoral heterogeneity stems from the spectrum of cancer cell clones and the dynamic cellular composition of the tumour microenvironment. Cross-patient heterogeneity is based on the multitude of cancer cells-of-origin and patient-specific combinations of germline and somatic genetic variants driving the tumorigenesis. Despite recent major ...