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VIB CMN - Computational Neurobiology University of Antwerp

Welcome to the Computational Neurobiology lab. In our lab we address fundamental questions in chromatin organisation, epigenetics and brain biology. We develop machine learning approaches for large-scale data integration and reconstruct cis-regulatory networks to understand how a cell "chooses" its fate. In particular, we focus on the role of chromatin organisation in neuronal cell fate specification and neurodegenerative disease, aiming to ...

Proteinchemistry, proteomics and epigenetic signalling(PPES) University of Antwerp

The cluster Proteinscience, proteomics and epigenetic signalling is active on three domains: neurodegeneration, infection and inflammation. For the first part the cluster studies for example the effects of hypoxia/ischemia and the role of hemeproteins herein and how this is perceived in metabolic active tissue such as brain. In the second part the virus-ghost relationship will be studie on intra- and extracellulair level. In the final part the ...

Biocrystallography KU Leuven

Responsible

The design of new potential drugs is traditionally the domain of the pharmacochemist. In the last decades Quantitative Structure-Activity Relationship (QSAR)-techniques are used more and more to define the 'essential' moieties of a pharmacon. A logical evolution in the search for the relation between the 3D-structure of drugs & their biological activity is the 3D-structure analysis of the biological target molecules and the receptor- ...