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Bridging the current gap between cancer cell biology - autonomous traits of malignant cells - and tumor biology - non-autonomous traits where, the unique features of the TME along with its cellular cross-talks are the main drivers of malignancy, understanding of the environmental cues and molecular pathways that participate in the interaction between cancer cells and stromal cells within the harsh TME.

Tackling cancer and in particular metastasis formation as a metabolic disease, mechanistically dissect the metabolic vulnerabilities of (metastasizing) cancer cells in the context of the tumor microenvironment and the metastatic niche to define novel therapeutic approaches to prevent cancer progression.