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The discovery and functional characterization of new, recurrent cytogenetic or molecular aberrations in malignant disorders are the most important research objectives of the laboratory for Genetics of Malignant Disorders. These research objectives connect almost seamlessly with the diagnostic, cytogenetic and molecular services which CME-UZ offers for nearly each malignant pathology: acute and chronic leukaemia, lymphomas, mesenchymal and ...

Our group focuses on:

(1) The development of wet-lab and computational methods for single-cell multi-omics analyses –including genome, epigenome and transcriptome analyses of single cells– using microarray and next-generation sequencing technologies. We furthermore automate these methods using customised liquid handling robotics and microfluidics.

(2) The application of these methods to study the nature, rate and mechanisms of ...