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Cellular Processes governed by protein conformational changes

• We investigate the regulation of (patho)physiological processes via reversible protein phosphorylation, and explore the therapeutic potential of the kinases and phosphatases involved. Focus is on Protein Kinase D (PKD) and Protein Phosphatase 2A (PP2A), but increasingly also on broader (kinome and phosphatome wide) approaches to systematically identify kinases/phosphatases that are implicated in (patho)physiological ...

The research unit Protein Chemistry (SPRO) goes back to 1967 when it was founded thanks to the joint efforts of Prof. R. Jeener (ULB) and Prof. L. Kanarek, who retired a few years ago. Originally, the research activities focused on the immunogenicity of hen egg white lysozyme and its proteolytic fragments. Since the early seventies, the research topics diversified. Over the years the lab developed original technologies for the purification of ...

Research on four types of functionally active proteins - Copper proteins : hemocyanins (involved in dioxygen binding). - Thiol proteins: metallothioneins (metal detoxication and donation). - Protease inhibitors: alpha -2-macroglobulin homologues. - Regulatory proteins: cytokines (defencesystems against infection). Aim: to determine, after their isolation or possible induction, the composition and the primary to quaternary structure of these ...