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Laboratory of Protein Phosphorylation and Proteomics KU Leuven

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  • We investigate the regulation of (patho)physiological processes via reversible protein phosphorylation, and explore the therapeutic potential of the kinases and phosphatases involved. Focus is on Protein Kinase D (PKD) and Protein Phosphatase 2A (PP2A), but increasingly also on broader (kinome and phosphatome wide) approaches to systematically identify kinases/phosphatases that are implicated in (patho)physiological ...

Proteinchemistry, proteomics and epigenetic signalling(PPES) University of Antwerp

The cluster Proteinscience, proteomics and epigenetic signalling is active on three domains: neurodegeneration, infection and inflammation. For the first part the cluster studies for example the effects of hypoxia/ischemia and the role of hemeproteins herein and how this is perceived in metabolic active tissue such as brain. In the second part the virus-ghost relationship will be studie on intra- and extracellulair level. In the final part the ...

Proteinscience, proteomics and epigenetic signaling (PPES) University of Antwerp

Within the department, the PPES lab studies molecular biological stress responses which affect cell viability, death, or senescence. The research cluster combines advanced molecular biochemical pharmacology, (chemo)proteomic, peptidomic and epigenomic systems biology approaches to identify biomarkers and druggable receptor-signaling targets for the control and the monitoring of therapy responses in chronic inflamm-aging diseases, several types ...