Laboratory for Dynamics of Biological Systems.
Our lab aims at providing a simpler view of the incredible complexity of biological systems, primarily focusing on the regulation of the cell cycle. We believe that understanding the system dynamics is essential to achieving this goal. In our studies we glean techniques from physics and mathematics, such as the theory of nonlinear dynamics and complex systems, which allows us to ...
Information processing in the brain depends on specialized circuits that are formed by distinct types of neurons. How these different nerve cells emerge and mature during development remains a fundamental question in neurobiology. We are interested to define at single-cell resolution the metabolic and transcriptomic programmes that shape neuronal diversity and circuit assembly in the developing mammalian cortex. Our research focuses primarily ...
The Scheele laboratory focuses on morphogenesis, homeostasis, and tumorigenesis of epithelial organs ranging from a cellular level to the organ scale. More specifically, the Scheele lab studies how healthy tissue architecture and environment prevent or promote the different steps of tumorigenesis. To study these highly dynamic processes, the Scheele lab utilizes and develops state-of-the-art imaging approaches, including 3D whole organ ...
Research activities in the group of "Theoretical Chemistry and Molecular Modelling" aim at linking domains of relevance in physical chemistry, chemical physics, and material research, such as:
- polymer physics and surfaces;
- electron structure theory of neutral and ionized molecules (anions, cations), clusters or radicals;
- advanced ionization spectroscopy (photoelectron spectroscopies [XPS, UPS, Synchrotron], Electron ...
The main focus of the research of the Laboratory of Molecular and Cellular Signaling is Ca2+ signalling in health and disease. We have a longstanding tradition in the investigation of cellular Ca2+ signalling both in single cells and in cell populations. We have developed a number of state-of-the-art techniques including fluorescence and confocal microscopy, luminescence and fluorescence multiplate reader, flux experiments with 45Ca2+ and a ...
Fundamental properties of the electronic excited state and of the use of this basic knowledge in different physical and physicochemical problems . - Intra- and intermolecular interactions in the electronic excited state. - Photochemistry and photophysics of ordered systems such as micelles, inverse micelles and membranes. Stabilization of ordered systems through polymerization. - Adsorption of organic molecules at surfaces and the influence ...
Research on four types of functionally active proteins - Copper proteins : hemocyanins (involved in dioxygen binding). - Thiol proteins: metallothioneins (metal detoxication and donation). - Protease inhibitors: alpha -2-macroglobulin homologues. - Regulatory proteins: cytokines (defencesystems against infection). Aim: to determine, after their isolation or possible induction, the composition and the primary to quaternary structure of these ...
Introduction
MPU explored the diversity of Leishmania and leishmaniases for over 25 years, ‘from genomes to eco-systems’. As such, we have developed a relevant laboratory experience in (i) parasitology and (ii) molecular biology both in the high-tech context of a modern lab and in the working conditions of a laboratory in a tropical context.
Since 2002, the unit is headed by Jean-Claude Dujardin, zoologist (Facultés Notre Dame ...
1.Streptomyces as host for heterologous protein production. It has aldready proven that Streptomyces is a good choice for heterologous protein production and can be an invaluable host for eukaryotic proteins. Some of these heterologous proteins are secreted as biologically active compounds in commercially significant yield using expression/secretion signals we have isolated (EP0851931A), they can easily be purified and have the same ...
The division Molecular Virology and Gene Therapy aims at developing novel therapeutics and diagnostics starting from basic research into the molecular cause of disease and employing the most advanced biomedical technologies. Research can be basic, applied or technological; in all cases our research aims at future applications in medicine.
Major disease areas are AIDS and Parkinson's disease. Other interests are gene therapy of cystic ...