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(URL:http://www.kuleuven.be/wieiswie/en/unit/52576632)Laboratory of E ndothelial Molecular Biology (Vesalius Research Center).

The goal of the Laboratory of Endothelial Molecular Biology (VRC) is to expand the current knowledge of how metabolism regulates endothelial redox homeostasis and vice-versa in healthy and diseased conditions. To accomplish this they have taken advantage of the innovative genetic and imaging ...

The Center for Molecular and Vascular Biology performs research related to the following topics:- Pathogenesis of thrombosis and bleeding. - Development of assays for the diagnosis of thrombosis and bleeding. – Signalling and transcription factor regulation in megakaryocytes and platelets. - Genetics for bleeding and thrombotic disorders. –(patho)physiology of megakaryopoiesis. – Role of transcription factors in endothelial heterogeneity. – ...

The research program of the Laboratory for Molecular Cancer Biology is devoted to the analysis of pathways governing the genesis, progression and maintenance of cancer.Our current research efforts follow from our recent studies on the p53 tumor suppressor. p53 is a transcription factor that functions as a central component of most cellular stress responses. The outcome of p53-mediated surveillance is closely dependent on the type of stress ...

The Laboratory of Molecular Biology of Leukemia tries to understand the genetic complexity of leukemia, with the aim to use that information to develop novel treatment strategies.

Leukemia is a genetically complex disease that is characterized by the accumulation of abnormal blood cells. The leukemia cells often harbor chromosomal defects and additional more sublte changes (mutations) in their genome. This information is used for ...

Research on four types of functionally active proteins - Copper proteins : hemocyanins (involved in dioxygen binding). - Thiol proteins: metallothioneins (metal detoxication and donation). - Protease inhibitors: alpha -2-macroglobulin homologues. - Regulatory proteins: cytokines (defencesystems against infection). Aim: to determine, after their isolation or possible induction, the composition and the primary to quaternary structure of these ...

MICH develops research in the following areas: 1. Fundamental research on the replication cycle of poliovirus, research concentrates on the first steps of the cycle (adsorption, uncoating) and the last step (assembly); 2. Development of new poliovaccines (also biotech vaccines); 3. Fundamental research on antiviral compounds (in collaboration with Janssen Research Foundation); 4. Viruses on the origin of multiple sclerosis?; 5. Theiler murine ...

The division Molecular Virology and Gene Therapy aims at developing novel therapeutics and diagnostics starting from basic research into the molecular cause of disease and employing the most advanced biomedical technologies. Research can be basic, applied or technological; in all cases our research aims at future applications in medicine.
Major disease areas are AIDS and Parkinson's disease. Other interests are gene therapy of cystic ...