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Our focus is on genetics, genomics and neuropathology of the neurodegenerative brain diseases Alzheimer's disease (AD), frontal temporal lobar degeneration (FTLD) and Parkinson's disease (PD), attempting to find molecular mechanisms of protein aggregation in dementia. We systematical collect large samples of patients and relatives for genetic studies aiming at identifying disease genes using either a positional cloning strategy in multiplex ...

The main research interest lies in the field of sensory genetics. Although work is done for different forms of sensory diseases, the emphasis is on nonsyndromic sensorineural hearing impairment and otosclerosis. Large families are collected in Belgium and The Netherlands, as well as in countries with high consanguinity rate such as Iran. These pedigrees are analyzed by linkage analysis. Subsequently, the genes involved are identified by ...

State of the art Inherited peripheral neuropathies belong to the most common neuromuscular disorders and occur worldwide (1/2500). The best known is Charcot-Marie-Tooth disease (CMT), an inherited disorder first described in 1886. Most patients have a progressive weakness and wasting of foot and hand muscles. Sometimes patients need walking aids or become wheelchair dependent even at a young age. The clinical variability and genetic ...