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Psychiatric disorders, such as major depression or unipolar disorder (UP), manic depression or bipolar disorder (BP) and schizophrenia, are among the most frequent brain diseases worldwide. An estimated 9-10% of the world population suffers from major depression, while bipolar disorder and schizophrenia each affect ~1% of the population. Although the precise causes of psychiatric diseases are still largely unknown, family studies argue for a ...

Our focus is on genetics, genomics and neuropathology of the neurodegenerative brain diseases Alzheimer's disease (AD), frontal temporal lobar degeneration (FTLD) and Parkinson's disease (PD), attempting to find molecular mechanisms of protein aggregation in dementia. We systematical collect large samples of patients and relatives for genetic studies aiming at identifying disease genes using either a positional cloning strategy in multiplex ...