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Gene Expression Unit KU Leuven

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We are interested in RNA expression of mammalian insulin producing pancreatic beta cells in order to explain how these cells function in normal health and how dysfunction can cause inappropriate release of insulin and diabetes. We study the profound phenotypic changes that occur in rodent beta cells during pregnancy. One of these changes concern serotonin production and secretion by a subpopulation of a heterogeneous beta cell population. ...

Research Group for Neurobiology and Gene Therapy KU Leuven

Responsible

The laboratory for Neurobiology and Gene Therapy is committed to gain insight in the underlying pathology of Parkinson's Disease (PD) and more recently Multiple System Atrophy (MSA), on both the molecular and cellular level. We are specifically focussing on the proteins α-synuclein and LRRK2, two key players in sporadic and familial PD.  The underlying idea is that better disease models and insights in the molecular pathogenesis are required ...

Division of Gene Therapy & Regenerative Medicine Vrije Universiteit Brussel

Convincing evidence continues to emerge from clinical trials that gene therapy is yielding therapeutic effects in patients suffering from a wide range of diseases. Moreover. the use of adult stem cells and the reprogramming of cells towards pluripotency are being heralded as some of the most promising developments in regenerative medicine at the forefront of medical innovation. This mirrors worldwide efforts in some of the leading research ...

Molecular Virology and Gene Therapy KU Leuven

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The division Molecular Virology and Gene Therapy aims at developing novel therapeutics and diagnostics starting from basic research into the molecular cause of disease and employing the most advanced biomedical technologies. Research can be basic, applied or technological; in all cases our research aims at future applications in medicine.
Major disease areas are AIDS and Parkinson's disease. Other interests are gene therapy of cystic ...

Department of Human Genetics KU Leuven

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The core business of the Center for Human Genetics is human and developmental genetics, neurogenetics and cancer genetics. For this reason we have chosen to structure the department around these three pillars by means of research programmes, headed by a program director.

Cell Genetics Vrije Universiteit Brussel

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The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related ...

Medical genetics of obesity and skeletal disorders (MGENOS) University of Antwerp

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The general aim of the research is to identify genes that are relevant for two multifactorial conditions, osteoporosis and obesity, in order to understand the pathogenesis of these conditions and to reveal novel putative therapeutic targets.In order to obtain this, the specific aims of our work are:- identification of genes for monogenic conditions with an abnormal bone density- identification of genes involved in rat models with an increased ...

Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research) KU Leuven

Responsible

The research is focused on the cellular and molecular basis of immune tolerance mechanisms and failure. They study genetic basis of immune tolerance through the generation of murine models of disease and the analysis of genetic defects in patients with immune disorders. The laboratory specializes in the study of regulatory T cells, primary immunodeficiencies, diabetes and T cell development.

Plant Genetics Vrije Universiteit Brussel

Responsible

Research in the Laboratory of Plant Genetics concerns basic plant molecular genetics as well as applied research relevant to the plant biotechnology and agricultural sector. The research is focused on the following themes: · DNA repair and recombination mechanisms and methods to influence these processes. This may lead to development of improved plant breeding techniques, improved plant transformation technology and new techniques for ...