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Gene Expression Unit KU Leuven

We are interested in RNA expression of mammalian insulin producing pancreatic beta cells in order to explain how these cells function in normal health and how dysfunction can cause inappropriate release of insulin and diabetes. We study the profound phenotypic changes that occur in rodent beta cells during pregnancy. One of these changes concern serotonin production and secretion by a subpopulation of a heterogeneous beta cell population. ...

Medical genetics of obesity and skeletal disorders (MGENOS) University of Antwerp

The general aim of the research is to identify genes that are relevant for two multifactorial conditions, osteoporosis and obesity, in order to understand the pathogenesis of these conditions and to reveal novel putative therapeutic targets. In order to obtain this, the specific aims of our work are: - identification of genes for monogenic conditions with an abnormal bone density - identification of genes involved in rat models with an increased ...

Applied Molecular Genomics University of Antwerp

Psychiatric disorders, such as major depression or unipolar disorder (UP), manic depression or bipolar disorder (BP) and schizophrenia, are among the most frequent brain diseases worldwide. An estimated 9-10% of the world population suffers from major depression, while bipolar disorder and schizophrenia each affect ~1% of the population. Although the precise causes of psychiatric diseases are still largely unknown, family studies argue for a ...

VIB CMN - Molecular Neurogenomics University of Antwerp

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The Lab focuses on the identification and characterization of disease-causing genes and pathways implicated in the molecular etiology of neurological disorders, like inherited peripheral neuropathies (CMT) and inherited epilepsies. For this purpose we use two major research strategies: - unraveling the role of aminoacyl-tRNA synthetases in peripheral neurodegeneration as a tool for understanding the molecular pathomechanisms of peripheral ...