The Laboratory of Molecular Endocrinologyis interested in the mechanisms by which androgens regulate transcription in different cell types and how this leads to their effects on fertility, on the prostate, the musculoskeletal system and other organs. We employ biochemical, molecular, cellular, genetic and in vivo approaches to investigate the functions and mechanisms of the androgen receptor in cellular, animal models and humans.
The action of steroid hormones (more specifically androgens and vitamin D) and of polypeptide hormones (more specifically calcium regulating hormones); the regulation of these hormones and their significance in human disease; the role of these hormones in normal and abnormal cellular differentiation. Development of new techniques for the measurement of hormones, hormone-binding proteins and hormone receptors. Development of new vitamin D ...
Endocrinology: The ovaries and other reproductive organs are in continuous interaction with the pituitary and the thyroid. The interplay may account for infertility occurring at different levels and may render the diagnosis difficult. Thyroid disorders, both hyperthyroidism and hypthyroidism, can interact with the ovaries, through a direct effect on the and indirect through alterations of the SHBG levels, the PRL levels and the coagulation ...