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There are five main research topics in the Laboratory of Experimental Oncology ( LEO):

• molecular characterization of rare tumors focused on identification of predictive biomarkers;
• preclinical efficacy studies of novel targeted agents in soft tissue sarcomas using a unique panel of xenograft models derived from patient samples;
• translational research, identifying prognostic markers related to experimental treatment, ...

The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.

There are four main topics of research which are closely related to major areas of clinical work. 1. Identifying prognostic and predictive biomarkers in breast cancer patients. 2. Molecular annotation of somatic mutations in sarcoma and the discovery and validation of genetic biomarkers and establishing cell lines and tumor xenografts. 3. Genetic polymorphism in melanoma; vitamin D and malignant melanoma; characterization of tumor response to ...