The Lab for Integrative cancer Genomics develops computational approaches to comprehensively chart genomic and epigenetic variation using sequencing data and elucidate their contributions to somatic evolution, tumour heterogeneity, and treatment resistance.
Cancers develop due to the accumulation of somatic mutations in the genome. The Laboratory for Cancer Genomics studies these mutations and leverages them to elucidate the evolutionary history of cancers. In this endeavour, we make use of new sequencing technologies and new bioinformatics analysis approaches.
Cancers are highly heterogeneous entities, both within a single tumor and across patients. Intratumoral heterogeneity stems from the spectrum of cancer cell clones and the dynamic cellular composition of the tumour microenvironment. Cross-patient heterogeneity is based on the multitude of cancer cells-of-origin and patient-specific combinations of germline and somatic genetic variants driving the tumorigenesis. Despite recent major ...
Our group focuses on:
(1) The development of wet-lab and computational methods for single-cell multi-omics analyses –including genome, epigenome and transcriptome analyses of single cells– using microarray and next-generation sequencing technologies. We furthermore automate these methods using customised liquid handling robotics and microfluidics.
(2) The application of these methods to study the nature, rate and mechanisms of ...
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
The Laboratory for Disease Mechanisms in Cancer conducts research into the link between the ribosome and cancer. The research questionson wich the laboratory focuses are:
1) What is the spectrum of acquired ribosome defects in cancer?
2) By what mechanisms do ribosome defects promote cancer?
3) Are ribosome defects therapeutically relevant?