(URL:http://www.kuleuven.be/wieiswie/en/unit/52576632)Laboratory of E ndothelial Molecular Biology (Vesalius Research Center).
The goal of the Laboratory of Endothelial Molecular Biology (VRC) is to expand the current knowledge of how metabolism regulates endothelial redox homeostasis and vice-versa in healthy and diseased conditions. To accomplish this they have taken advantage of the innovative genetic and imaging ...
Part of the Department of Oncology that fosters synergy in innovative oncological research. By creating a close link between bed and bench and by capitalizing on advanced technologies, our researchers aim to unravel key molecular mechanisms underlying the development and progression of cancer and to maximize opportunities to translate these findings into better clinical biomarkers, adaptive strategies and innovative treatments.
The Laboratory of Growth Control and Cancer Research conducts reasearch on the mechanisms that control organ size. Currently they focus on three main topics: 1) How mechanical forces regulate cellular behavior and the Hippo pathway, 2) The regulation of cell competition and the role of the Hippo pathway therein, and 3) The role of the Hippo pathway in cancer cell dormancy. These three projects are highly related and interconnected and aim at ...
The Laboratory of Lipid Metabolism and Cancer focusses on altered lipid metabolism in cancer cells. Using a state-of-the-art mass spectrometry-based lipidomics technology the group has made the intriguing observation that development and progression of cancer is almost invariably accompanied by dramatic changes in the cell’s composition of phospholipids. As phospholipids play a key role in the formation of membranes, which organize numerous ...
The Laboratory for Disease Mechanisms in Cancer conducts research into the link between the ribosome and cancer. The research questionson wich the laboratory focuses are:
1) What is the spectrum of acquired ribosome defects in cancer?
2) By what mechanisms do ribosome defects promote cancer?
3) Are ribosome defects therapeutically relevant?
The research program of the Laboratory for Molecular Cancer Biology is devoted to the analysis of pathways governing the genesis, progression and maintenance of cancer.Our current research efforts follow from our recent studies on the p53 tumor suppressor. p53 is a transcription factor that functions as a central component of most cellular stress responses. The outcome of p53-mediated surveillance is closely dependent on the type of stress ...
Cancers are highly heterogeneous entities, both within a single tumor and across patients. Intratumoral heterogeneity stems from the spectrum of cancer cell clones and the dynamic cellular composition of the tumour microenvironment. Cross-patient heterogeneity is based on the multitude of cancer cells-of-origin and patient-specific combinations of germline and somatic genetic variants driving the tumorigenesis. Despite recent major ...
Laboratory for RNA Cancer Biology is a division of the Department of Oncology that fosters synergy in innovative oncological research. By creating a close link between bed and bench and by capitalizing on advanced technologies, our researchers aim to unravel key molecular mechanisms underlying the development and progression of cancer and to maximize opportunities to translate these findings into better clinical biomarkers, adaptive ...
Cancers develop due to the accumulation of somatic mutations in the genome. The Laboratory for Cancer Genomics studies these mutations and leverages them to elucidate the evolutionary history of cancers. In this endeavour, we make use of new sequencing technologies and new bioinformatics analysis approaches.