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Frontotemporal Dementia (FTD) represents 10-20% of all dementias and is clinically important because of its early onset and its dramatic impact on core human qualities, including personality, insight and verbal communication. Research in our group is focused on the discovery and functional characterization of novel disease genes implicated in FTD and related disorders. Our group leads world-wide consortia focused on two important pathological ...

Welcome to the Computational Neurobiology lab. In our lab we address fundamental questions in chromatin organisation, epigenetics and brain biology. We develop machine learning approaches for large-scale data integration and reconstruct cis-regulatory networks to understand how a cell "chooses" its fate. In particular, we focus on the role of chromatin organisation in neuronal cell fate specification and neurodegenerative disease, aiming to ...

The research unit is committed to increase insight in the complex genetics of Alzheimer's disease and to investigate the translational potential of genetic discovery. We use genetic-epidemiological methods and advanced genomic technologies to identify molecular mechanisms that can serve as future targets for early detection, prevention and treatment. Techniques include 2nd and 3rd generation DNA and RNA sequencing on various biomaterials, ...

Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer's disease (AD) and Frontotemporal dementia (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the ...

The Lab focuses on the identification and characterization of disease-causing genes and pathways implicated in the molecular etiology of neurological disorders, like inherited peripheral neuropathies (CMT) and inherited epilepsies. For this purpose we use two major research strategies: - unraveling the role of aminoacyl-tRNA synthetases in peripheral neurodegeneration as a tool for understanding the molecular pathomechanisms of peripheral ...

Our focus is on genetics, genomics and neuropathology of the neurodegenerative brain diseases Alzheimer's disease (AD), frontal temporal lobar degeneration (FTLD) and Parkinson's disease (PD), attempting to find molecular mechanisms of protein aggregation in dementia. We systematical collect large samples of patients and relatives for genetic studies aiming at identifying disease genes using either a positional cloning strategy in multiplex ...

T cells are a central component of the adaptive immune response. T cells are crucial to maintaining protection against infections and immune tolerance. Our primary focus is understanding the role of T cells in brain function and disease. We use a multidisciplinary approach integrating immunology and neuroscience to gain mechanistic insights into the contribution of T cells to brain plasticity and identify molecular targets for the development of ...