Find expertise

The research unit Brain and Cognition consists of the following laboratories:

• Laboratory for Biological Psychology
• Laboratory for Experimental Psychology

Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.

Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.

The Laboratory for Dystonia Research investigates dystonia pathophysiology. They predominantly focus on the molecular and cellular pathology of hereditary dystonia, but also have long-term goals of determining neurological defects and identifying therapeutic targets to treat dystonia.

We want to force a breakthrough in the cure of neuronal and neurodegenerative disorders. This requires a deep understanding of normal brain function and translation of this knowledge into a solid mechanistic understanding of disease mechanisms.

The Laboratory for the Research of Neurodegenerative Diseases performes research into the fundamental molecular processes that underlay neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Their work has also contributed to insights into general physiologically mechanisms, in particular, the understanding of regulated intramembrane proteolysis as an important signaling mechanism in health and disease. They have demonstrated the ...

The research in the Laboratory of Membrane Trafficking is focused on the cell biology and trafficking of the g-secretase components. This multiprotein complex has been implicated in a new signal transduction paradigm, called Regulated Intramembrane Proteolysis or RIP and is critical in a wide variety of important cellular activities including embryogenesis, brain development and haematopoiesis. RIP also plays a central role in Alzheimer's ...

The Laboratory of Neurobiology focuses on the mechanisms of acute and chronic axonal and neuronal degeneration and regeneration, aiming to contribute to the development of new therapeutic strategies for neurodegenerative disorders. We intensively study motor neuron diseases (amyotrophic lateral sclerosis (ALS) and hereditary motor neuropathies), frontotemporal dementia (FTD) and stroke.