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The BBCO research group focuses its research on the comprehensive study of mental processes and their biological (brain and body) correlates in different domains of human functioning and behavior, such as cognition, social judgment, affect, well-being and sleep. Without doubt, the study of the brain and body, and its related mental processes is at the forefront of current research in many disciplines of psychology. Together with behavioral ...

Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.

The Laboratory for Dystonia Research investigates dystonia pathophysiology. They predominantly focus on the molecular and cellular pathology of hereditary dystonia, but also have long-term goals of determining neurological defects and identifying therapeutic targets to treat dystonia.

The research unit Brain and Cognition consists of the following laboratories:

• Laboratory for Biological Psychology
• Laboratory for Experimental Psychology

The long-term goal of Laboratory of Glia Biologyis to understand the molecular mechanisms that control development and function of astrocytes in vivo, and how they interact with neurons.
Our strategy is to use astrocytes isolated from mouse brain as a starting point. This allows us to effectively take a “bottom up” approach to astrocyte function. In a first step, we are combining state-of-the-art biochemical and physiological techniques ...

We want to force a breakthrough in the cure of neuronal and neurodegenerative disorders. This requires a deep understanding of normal brain function and translation of this knowledge into a solid mechanistic understanding of disease mechanisms.

The Laboratory for the Research of Neurodegenerative Diseases performes research into the fundamental molecular processes that underlay neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Their work has also contributed to insights into general physiologically mechanisms, in particular, the understanding of regulated intramembrane proteolysis as an important signaling mechanism in health and disease. They have demonstrated the ...

The research in the Laboratory of Membrane Trafficking is focused on the cell biology and trafficking of the g-secretase components. This multiprotein complex has been implicated in a new signal transduction paradigm, called Regulated Intramembrane Proteolysis or RIP and is critical in a wide variety of important cellular activities including embryogenesis, brain development and haematopoiesis. RIP also plays a central role in Alzheimer's ...

The research interests of the Laboratory of Neuronal Communication are defined as:

Altered synaptic communication has been identified as one of the leading causes of various neurological and psychiatric disorders, yet the underlying molecular mechanisms remain unresolved. Hence, establishing an understanding of synaptic communication at the molecular level in relation to neurological disease, in particular Parkinson’s disease, would be ...