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Using a large panel of classical morphological techniques incl. enzyme- andimmunohistochemistry, as well as more advanced molecular techniques on tissue sections, we investigate the histology & the function of a variety of human tissues in normal & in pathological conditions.Throughout these research activities we attempt to optimise the available morphological techniques for light microscopy, electron microscopy, incl. transmission ...

The Laboratory of Cell Death Research & Therapy researches Defective regulation of cell death, especially in the form of apoptosis, contributes to the development of crucial pathologies including cancer and plays a major role in chemoresistance. Mechanisms regulating cancer cell death also affect the emission of ‘danger signals’ from the stressed/dying cells, which critically define their ‘immunogenic character’ and impact the initiation ...

The Laboratory for Cell Stress & Immunity (CSI) focusses on following research themes: cancer immunology & immunotherapy (e.g. DC vaccines, immune-checkpoint blockers, chemo-immunotherapy), immunology of cancer cell death (e.g. programmed cell death like apoptosis, necrosis & necroptosis; stress responses, inflammation, immunity), stress or therapy-elicited immune-signalling pathways (e.g. type I interferons, NFkB signalling, ...